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4-Hydroxy-2-nonenal increases superoxide anion radical in endothelial cells via stimulated GTP cyclohydrolase proteasomal degradation

To protect cells from oxidative stress, glutathione competes with other antioxidants when reducing ROS

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doi:10.1097/JCP.0b013e31829a83f5 15

PARP cleavage inhibition: PARP, a downstream target of caspase-3, saw its cleavage fragments reduced by 77.5%

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